An arguments of altering the ageing in humans and generating natural life into a controlled environm

Sirtuin in turn inhibits mTOR.

what is the biological cause for human aging

Gerontologists disagree about the extent to which age-related diseases should be considered integral features of that phenotype. Masoro E.

This resetting into a juvenile state was experimentally achieved in by activating the four Yamanaka DNA transcription factors — Sox2Oct4Klf4 and c-Myc which have previously been routinely used for producing young animals from cloned adult skin cells.

cellular aging theory

The body's DNA is so vital that the natural repair processes kick in when an error is made. Population ageing is a direct result of the decrease in the fertility rate and the increase in life expectancy.

Programmed theory of aging

Accumulated mutations theory It was first proposed by Medawar in Gene Mutation Theory In the s, the scientists investigated the role of mutations in aging. Experts believe that may be due to ongoing inflammation in blood vessels. This traditional definition was recently challenged in the new encyclopedia of Gerontology Birren, , where aging was specifically defined as the process of a system's deterioration through time. Several theories have been proposed to explain the nature of aging. Placental mammals have ample opportunity for a variety of stochastic processes to take place during their long reproductive and postreproductive phases. Thus, oxidative stress-related multisystem dysfunction could result in the performance deficit associated to frailty phenotype either including or not sarcopenia phenotype. These data were looking for a better balance in order to delay and improve the aging process Alcantud and Sotos, Telomerase appears to repair and replace the telomeres manipulating the "clocking" mechanism that controls the life span of dividing cells Allen, ; Bodnar et al. Several studies have shown up the possible influence of melatonin in persons with sleep disorders. But cardiovascular disease and cancer, not pulmonary disease, are the major causes of death.

Although this theory failed to completely explain the aging process, the prominent role of oxidative damage in the decline of function coursing with aging in different tissues is widely accepted.

Life span, however, is a constitutional feature of a species, and, although environmental agents can readily modulate the life expectancy of populations, in most instances the life span is not influenced. Arbitrary divisions set to mark periods of life may include: juvenile via infancychildhoodpreadolescenceadolescenceearly adulthoodmiddle adulthoodand late adulthood.

Protein-Synthesis Error Catastrophe Orgelargued that mistakes in the synthesis of proteins that participate in the machinery of protein synthesis, at either the transcriptional or translational level, have the potential, through a positive-feedback loop, to cause a general exponential loss in the fidelity of protein synthesis.

Its role in aging, in the physiopathology of numerous degenerative processes, in the side effects associated with the above mentioned processes, as well as its utility in the prognosis of diverse diseases, is something that every day finds a major experimental and clinical support.

theories of aging

Possibly there are a series of processes of different category and importance involved in the aging.

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Principles of Gerontology